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Heparin, porcine mucosa (China)

Changzhou (Jiangsu), China31.81°N 119.97°E
computed criticality20/100
reading
≈80% of global supply and 74% of US supply derived from porcine mucosa, mostly Chinese
2024
Fault line

Heparin, the reference anticoagulant in surgery and dialysis, is extracted from porcine intestinal mucosa whose collection China, the leading pig producer, dominates. The 2008 scandal, a contaminant, oversulfated chondroitin, causing about a hundred deaths in the United States, revealed the fragility of this diffuse, poorly traceable biological chain. African swine fever, which decimated the Chinese herd, casts a recurring risk of disruption.

Actors
Crude heparin producers of Jiangsu and Shandong
Pfizer / Hospira (finishing)
Sanofi (finishing)
Feeds 2
Drug shortages, FDA / EMA / WHOPharma & APIsPort of Shanghai, YangshanChokepoints
Sources